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Harry van Steeg Selected Research

DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes)

1/2021Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice.
9/2011Deregulation of cancer-related pathways in primary hepatocytes derived from DNA repair-deficient Xpa-/-p53+/- mice upon exposure to benzo[a]pyrene.
1/2010Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells.
10/2009Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models.
3/2009DNA repair-deficient Xpa/p53 knockout mice are sensitive to the non-genotoxic carcinogen cyclosporine A: escape of initiated cells from immunosurveillance?
12/2008DNA-repair-deficient Rad54/Rad54B mice are more sensitive to clastogens than wild-type mice.
4/2006Phenacetin acts as a weak genotoxic compound preferentially in the kidney of DNA repair deficient Xpa mice.
3/2006IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression.
2/2005Molecular misreading: the frequency of dinucleotide deletions in neuronal mRNAs for beta-amyloid precursor protein and ubiquitin B.
1/2005Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair.
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Harry van Steeg Research Topics

Disease

21Neoplasms (Cancer)
03/2019 - 03/2003
11DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes)
01/2021 - 03/2003
6Inflammation (Inflammations)
01/2019 - 03/2007
5Cockayne Syndrome (Syndrome, Cockayne)
06/2013 - 08/2006
4Xeroderma Pigmentosum (Kaposi's Disease)
11/2011 - 03/2002
3Carcinoma (Carcinomatosis)
03/2019 - 03/2002
3Breast Neoplasms (Breast Cancer)
02/2015 - 03/2002
3Contact Dermatitis (Eczema, Contact)
03/2006 - 10/2003
2Lung Neoplasms (Lung Cancer)
03/2016 - 03/2015
2Alzheimer Disease (Alzheimer's Disease)
01/2016 - 02/2005
2Trichothiodystrophy Syndromes
08/2006 - 05/2002
2Carcinogenesis
01/2005 - 03/2002
1Frailty
01/2019
1Liver Diseases (Liver Disease)
12/2014
1Fibrosis (Cirrhosis)
12/2014
1Reperfusion Injury
01/2014
1Death (Near-Death Experience)
01/2014
1Lymphoma (Lymphomas)
03/2009
1Adenocarcinoma
03/2009
1Starvation
08/2008
1Pneumonia (Pneumonitis)
08/2008
1Body Weight (Weight, Body)
01/2008
1Urinary Bladder Neoplasms (Bladder Cancer)
08/2007
1Lung Injury
03/2007
1Hypoglycemia (Reactive Hypoglycemia)
01/2007
1Atrophy
12/2006
1Progeria (Hutchinson Gilford Syndrome)
08/2006
1Kidney Neoplasms (Kidney Cancer)
04/2006
1Sarcoma (Soft Tissue Sarcoma)
09/2005
1Down Syndrome (Down's Syndrome)
02/2005
1Neuroblastoma
02/2005
1Skin Neoplasms (Skin Cancer)
01/2005
1Weight Loss (Weight Reduction)
09/2004
1Genomic Instability
02/2002

Drug/Important Bio-Agent (IBA)

6Proteins (Proteins, Gene)FDA Link
12/2014 - 03/2002
6CarcinogensIBA
01/2013 - 01/2007
4Biological ProductsIBA
02/2015 - 08/2008
4EnzymesIBA
12/2014 - 03/2002
4DNA (Deoxyribonucleic Acid)IBA
01/2014 - 03/2002
3OzoneIBA
08/2008 - 03/2003
32-Acetylaminofluorene (2 Acetylaminofluorene)IBA
08/2007 - 08/2004
2AntioxidantsIBA
01/2019 - 01/2007
2Codon (Codons)IBA
03/2016 - 03/2015
2lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA
01/2014 - 03/2009
2Oxygen (Dioxygen)IBA
11/2011 - 03/2008
2Benzo(a)pyreneIBA
09/2011 - 03/2003
2MutagensIBA
01/2010 - 12/2008
2Air Pollutants (Pollutants, Air)IBA
08/2008 - 03/2007
2Oxidants (Oxidizing Agents)IBA
08/2008 - 03/2007
2bis(tri-n-butyltin)oxide (tributyltin oxide)IBA
01/2008 - 12/2006
2Serine (L-Serine)FDA Link
08/2007 - 10/2004
2A-Form DNA (A-DNA)IBA
02/2007 - 05/2002
2Interleukin-12 (IL 12)IBA
03/2006 - 01/2005
1Sirolimus (Rapamycin)FDA Link
01/2021
1Irinotecan (Camptosar)FDA LinkGeneric
03/2019
1Biomarkers (Surrogate Marker)IBA
01/2019
1Amyloid (Amyloid Fibrils)IBA
01/2016
1MelatoninIBA
07/2015
1Vitamin DFDA LinkGeneric
07/2015
17,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideIBA
03/2015
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
02/2015
1Insulin (Novolin)FDA Link
02/2015
1Insulin Glargine (Lantus)FDA Link
02/2015
1Phosphotransferases (Kinase)IBA
02/2015
1LigandsIBA
12/2014
1Steroid 12-alpha-Hydroxylase (CYP8B1)IBA
12/2014
1XenobioticsIBA
12/2014
1CytosineIBA
01/2013
1Peroxisome ProliferatorsIBA
11/2012
1MetalloidsIBA
11/2012
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
11/2009
1Protein Isoforms (Isoforms)IBA
11/2009
1Pyrimidine DimersIBA
11/2009
1Cyclosporine (Ciclosporin)FDA LinkGeneric
03/2009
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2008
1Interleukin-6 (Interleukin 6)IBA
08/2008
1Liver GlycogenIBA
01/2007
1Insulin-Like PeptidesIBA
01/2007
1Growth Hormone (Somatotropin)IBA
01/2007
1NucleotidesIBA
08/2006
1PhenacetinIBA
04/2006
1Analgesics (Analgesic Drugs)IBA
04/2006
1Interleukin-18 (Interleukin 18)IBA
03/2006
19,10-Dimethyl-1,2-benzanthraceneIBA
09/2005
1Estrogen Receptor alphaIBA
09/2005
1Amyloid beta-PeptidesIBA
02/2005
1UbiquitinIBA
02/2005
1Messenger RNA (mRNA)IBA
02/2005
1RNA (Ribonucleic Acid)IBA
02/2005
1Deoxyribodipyrimidine Photo-LyaseIBA
01/2005
1Diethylhexyl Phthalate (DEHP)IBA
09/2004
1Picryl Chloride (Trinitrochlorobenzene)IBA
10/2003
1Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA
03/2003
1DNA AdductsIBA
03/2003
1A-factor (Streptomyces)IBA
03/2002
1Eflornithine (Ornidyl)FDA Link
03/2002
1Tumor Suppressor Protein p53IBA
02/2002

Therapy/Procedure

1Diet Therapy (Therapy, Diet)
01/2021
1Therapeutics
02/2015
1Kidney Transplantation
01/2014